Haemoglobin A1c (HbA1c)

Meta Analysis

Matrix: Whole Blood

Type median CV estimate lower CI limit higher CI limit Date Updated Tools
Within-subject
1.2
0.3
2.5
2020-03-26 19:44:30 UTC

References

No meta analysis Reference included in meta calculation Reference not included in meta calculation
Link Estimate of CVi Estimate of CVg Gender State of Well Being Matrix
Seasonal and biological variation of blood concentrations of total cholesterol, dehydroepiandrosterone sulfate, hemoglobin A1C, IgA, prolactin and free testosterone in healthy women, Garde AH, Hansen AM, Skovgaard LT and Christensen JM, 2000, Clin Chem, 46, 551-9 2.6 3.3 Females Healthy (excl pregnant) Whole Blood EDTA
Biological variation of hemoglobin A1c: consequences for diagnosing diabetes mellitus., Lenters-Westra E, Roraas T, Schidhelm RK, Sligerland RJ and Sandberg S , 2014, Clin Chem, 60, 1570-2 1.7 8.0 Mixed Healthy (excl pregnant) Whole Blood EDTA
Circannual temperature-related variation in hemoglobin A1c is unlikely to affect its use as a diagnostic test for type 2 diabetes, Xue L, Liang H and Jiang X , 2012, Clin Lab, 58, 481-8 2.29 6.52 Mixed Healthy (excl pregnant) Whole Blood EDTA
Biological variation of hemoglobin A1c: consequences for diagnosing diabetes mellitus., Lenters-Westra E, Roraas T, Schidhelm RK, Sligerland RJ and Sandberg S , 2014, Clin Chem, 60, 1570-2 1.4 6.7 Mixed Healthy (excl pregnant) Whole Blood EDTA
Biological variation of glycated hemoglobin. Implications for diabetes screening and monitoring, Kilpatrick ES, Maylor PV and Keevil BG, 1998, Diabetes Care, 21, 261-4 1.9 6.8 Mixed Healthy (excl pregnant) Whole Blood EDTA
Seasonal and biological variation of blood concentrations of total cholesterol, dehydroepiandrosterone sulfate, hemoglobin A1C, IgA, prolactin and free testosterone in healthy women, Garde AH, Hansen AM, Skovgaard LT and Christensen JM, 2000, Clin Chem, 46, 551-9 0.7 3.3 Females Healthy (excl pregnant) Whole Blood EDTA
Within subject biological variation of glucose and HbA1c in healthy persons and in type 1 diabetes patients, Carlsen S, Petersen PH, Skeie S, Skadberg O and Sandberg S, 2011, Clin Chem Lab Med, 49, 1501-7 1.2 5.7 Mixed Healthy (excl pregnant) Whole Blood EDTA
Revaluation of biological variation of glycated hemoglobin (HbA1c) using an accurately designed protocol and an assay traceable to the IFCC reference system, Braga F, Dolci A, Montagnana M, Pagani F, Paleari R, Guidi GC, Mosca A and Panteghini M, 2011, Clin Chim Acta, 412, 1412-6 2.5 7.1 Mixed Healthy (excl pregnant) Whole Blood EDTA
Estimation of biological variation and reference change value of glycated hemoglobin (HbA1c) when two analytical methods are used, Ucar F, Erden G, Ginis Z, Ozturk G, Szser S, Gurler M and Guneyk A, 2013, Clin Biochem, 46, 1548-53 1.17 5.75 Mixed Healthy (excl pregnant) Whole Blood EDTA
Evaluation of biological variation of glycated hemoglobin and glycated albumin in healthy Chinese subjects, Liang L, He H, Zhang M et al, 2019, J Clin Lab Anal, 33, e22715 0.29 4.32 Mixed Healthy (excl pregnant) Whole blood
Estimation of biological variation and reference change value of glycated hemoglobin (HbA1c) when two analytical methods are used, Ucar F, Erden G, Ginis Z, Ozturk G, Szser S, Gurler M and Guneyk A, 2013, Clin Biochem, 46, 1548-53 2.15 4.03 Mixed Healthy (excl pregnant) Whole Blood EDTA
Revaluation of biological variation of glycated hemoglobin (HbA1c) using an accurately designed protocol and an assay traceable to the IFCC reference system, Braga F, Dolci A, Montagnana M, Pagani F, Paleari R, Guidi GC, Mosca A and Panteghini M, 2011, Clin Chim Acta, 412, 1412-6 3.2 5.1 Females Healthy (excl pregnant) Whole Blood EDTA
Intensive diabetes management requires very precise testing of glycohemoglobin, Kolatkar NS, Cembrowski GS, Callahan PL and Etzwiler DD, 1994, Clin Chem, 40, 1608-9 2.4 Males Non-healthy (excl pregnant) Unknown
Estimation of biological variation and reference change value of glycated hemoglobin (HbA1c) when two analytical methods are used, Ucar F, Erden G, Ginis Z, Ozturk G, Szser S, Gurler M and Guneyk A, 2013, Clin Biochem, 46, 1548-53 1.41 2.04 Males Healthy (excl pregnant) Whole Blood EDTA
Intensive diabetes management requires very precise testing of glycohemoglobin, Kolatkar NS, Cembrowski GS, Callahan PL and Etzwiler DD, 1994, Clin Chem, 40, 1608-9 4.1 Males Non-healthy (excl pregnant) Unknown
Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos, Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 2.2 20.39 Mixed Healthy (excl pregnant) Whole Blood EDTA
Circannual temperature-related variation in hemoglobin A1c is unlikely to affect its use as a diagnostic test for type 2 diabetes, Xue L, Liang H and Jiang X , 2012, Clin Lab, 58, 481-8 15.14 Mixed Non-healthy (excl pregnant) Whole Blood EDTA
Variability of glycated hemoglobin levels in the first year post renal transplantation in patients without diabetes, Pimentel AL and Camargo JL, 2017, Clin Biochem, 50, 997-1001 4.4 7.0 Mixed Healthy (excl pregnant) Whole Blood EDTA
Estimation of biological variation and reference change value of glycated hemoglobin (HbA1c) when two analytical methods are used, Ucar F, Erden G, Ginis Z, Ozturk G, Szser S, Gurler M and Guneyk A, 2013, Clin Biochem, 46, 1548-53 1.23 5.75 Females Healthy (excl pregnant) Whole Blood EDTA
Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos, Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 2.0 19.98 Males Healthy (excl pregnant) Whole Blood EDTA
Estimate of biological variation of laboratory analytes based on the third National Health and Nutrition Examination Survey, Lacher DA, Hughes JP and Carroll MD, 2005, Clin Chem, 51, 450-2 9.6 Mixed Healthy (excl pregnant) Whole blood
Within subject biological variation of glucose and HbA1c in healthy persons and in type 1 diabetes patients, Carlsen S, Petersen PH, Skeie S, Skadberg O and Sandberg S, 2011, Clin Chem Lab Med, 49, 1501-7 1.7 8.2 Males Non-healthy (excl pregnant) Whole blood
Circannual temperature-related variation in hemoglobin A1c is unlikely to affect its use as a diagnostic test for type 2 diabetes, Xue L, Liang H and Jiang X , 2012, Clin Lab, 58, 481-8 5.82 14.0 Mixed Non-healthy (excl pregnant) Whole Blood EDTA
Estimate of biological variation of laboratory analytes based on the third National Health and Nutrition Examination Survey, Lacher DA, Hughes JP and Carroll MD, 2005, Clin Chem, 51, 450-2 1.5 Mixed Healthy (excl pregnant) Whole blood
Biological variation of glycated haemoglobin in a paediatric population and its application to calculation of significant change between results, Desmeules P, Cousineau J, Allard P, 2010, Ann Clin Biochem, 47, 35-8 4.8 12.8 Males Non-healthy (excl pregnant) Unknown
Clinical utility of assays of glycosilated haemoglobin and serum fructosamine comapred: use of data on biological variation, Howey JEA, Bennet WM, Browning MCK, Jung RT and Fraser CG, 1989, Diabetic Medicine, 6, 793-6 7.3 10.8 Mixed Non-healthy (excl pregnant) Whole Blood EDTA
Estimation of biological variation and reference change value of glycated hemoglobin (HbA1c) when two analytical methods are used, Ucar F, Erden G, Ginis Z, Ozturk G, Szser S, Gurler M and Guneyk A, 2013, Clin Biochem, 46, 1548-53 1.04 4.75 Males Healthy (excl pregnant) Whole Blood EDTA
Serum fructosamine and glycosylated haemoglobin in the monitoring of glycaemic control in insulin-dependent diabetic outpatients, Watts CF, Morris RW, Goodland FC, Kubal C and Shaw KM, 1989, Practical Diabetes, 6, 159-63 9.14 20.2 Males Non-healthy (excl pregnant) Whole Blood EDTA
Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos, Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 2.0 20.62 Females Healthy (excl pregnant) Whole Blood EDTA
Reference change value for HbA1C in patients with type 2 Diabetes Mellitus, Trapé J, Aliart M, Brunet M, Dern E, Abadal E and Queraltó JM , 2000, Clin Chem Lab Med, 38, 1283-7 7.9 Males Non-healthy (excl pregnant) Whole Blood EDTA
Estimation of biological variation and reference change value of glycated hemoglobin (HbA1c) when two analytical methods are used, Ucar F, Erden G, Ginis Z, Ozturk G, Szser S, Gurler M and Guneyk A, 2013, Clin Biochem, 46, 1548-53 2.38 4.53 Females Healthy (excl pregnant) Whole Blood EDTA
Reference change value for HbA1C in patients with type 2 Diabetes Mellitus, Trapé J, Aliart M, Brunet M, Dern E, Abadal E and Queraltó JM , 2000, Clin Chem Lab Med, 38, 1283-7 5.4 Males Non-healthy (excl pregnant) Whole Blood EDTA
Reference change value for HbA1C in patients with type 2 Diabetes Mellitus, Trapé J, Aliart M, Brunet M, Dern E, Abadal E and Queraltó JM , 2000, Clin Chem Lab Med, 38, 1283-7 3.9 Males Non-healthy (excl pregnant) Whole Blood EDTA
Reference change value for HbA1C in patients with type 2 Diabetes Mellitus, Trapé J, Aliart M, Brunet M, Dern E, Abadal E and Queraltó JM , 2000, Clin Chem Lab Med, 38, 1283-7 4.3 Males Non-healthy (excl pregnant) Whole Blood EDTA
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