EFLM Biological Varation Database : BIVAC Minimum Data Set for Alanine transaminase (ALT) EFLM Biological Variation

Alanine transaminase (ALT)

Reference

Statland BE, Winkel P and Bokelund H, 1973, Clin Chem, 19, 1374-9 , Factors contributing to intra-individual variation of serum constituents: 1. within-day variation of serum constituents in healthy subjects

Originally from this reference: Clin Chem, Statland BE, Winkel P and Bokelund H, 1973

ID: 0266

Scoring

Total Score

C_4,8,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	C
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	B
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	A
11. ANOVA	B
12. CI	A
13. No of Results	C
14. Concentrations	A
15. Total Score	C_4,8,13
Comment	Method different from IFCC

Item Details

Parameter	Score
Matrix	Serum
Measurand	Alanine transaminase (ALT)
Unit	U / L
Overall Analytical Principle Method	Enzymatic analysis - Not specified
Number of Subjects	11
Number of Subjects included in BV estimation	11
Ethinicity	Caucasian
Age Mean / Median
Age Min	21.0
Age Max	27.0
Age SD
Number of Males	11
Number of Females
State of Well Being	Healthy (excl pregnant)
Study Duration Length	1
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	3
Interval Units	Day
Sampling Times	Start Time: 08:00 End Time: 14:00
Number of Samples	3
Average Number of Samples Used for BV Estimation	3.0
Average Number of Replicates	2.0
Estimates of CVi	6.7
Calculated Confidence Intervals of CVi	Lower: 4.74, Upper: 9.94
Estimates of CVg	83.9
Calculated Confidence Intervals of CVg	Lower: 0.00, Upper: 142.57
Analytical CV	4.2
Calculated Confidence Intervals of Analytical CV	Lower: 3.39, Upper: 5.53
Measurand Mean	17.3
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	true
Adult Population	true
Weekly Samplings	false
Reviewed	true
Published	true
Gender for Meta-Analysis	Males
Snomed CT
NPU
LOINC
Comment	within day

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