Reference
Pineda-Tenor D , Laserna-Mendieta EJ, Timon-Zapata J, Rodelgo-Jimenez L, Ramos-Corral R, Recio-Montealegre A and Gomez-Serranillos Reus M, 2013, Clin Chem Lab Med, 51, 851-62 , Biological variation and reference change value of common clinical chemistry and haematologic laboratory analytes in the eldery population
| Parameter | Score |
|---|---|
| 1. Scale | A |
| 2. Study Population | A |
| 3. Samples | A |
| 4. Measurand | A |
| 5. Pre-Analytical | B |
| 6. Replicate Analysis | B |
| 7. Steady State | B |
| 8. Outlier Analysis | C |
| 9. Normality | B |
| 10. Variance Homogeneity | A |
| 11. ANOVA | B |
| 12. CI | A |
| 13. No of Results | C |
| 14. Concentrations | A |
| 15. Total Score | C8,13 |
| Comment |
| Parameter | Score |
|---|---|
| Matrix | Serum |
| Measurand | Aspartate transaminase (AST) |
| Unit | micromol / L |
| Overall Analytical Principle Method | Enzymatic analysis - IFCC method |
| Number of Subjects | 64 |
| Number of Subjects included in BV estimation | |
| Ethinicity | Caucasian |
| Age Mean / Median | |
| Age Min | 80.0 |
| Age Max | 89.0 |
| Age SD | |
| Number of Males | |
| Number of Females | 64 |
| State of Well Being |
Healthy (excl pregnant)
|
| Diseases | |
| Study Duration Length | 30 |
| Study Duration Units | Week |
| Sampling Intervals, e.g. X sample(s) per Interval Unit | 1 |
| Interval Units | Week |
| Sampling Times | Start Time:
08:00
End Time: 10:00 |
| Number of Samples | 4 |
| Average Number of Samples Used for BV Estimation | 4.0 |
| Average Number of Replicates | 1.0 |
| Estimates of CVi | 18.3 |
| Calculated Confidence Intervals of CVi | Lower: 16.56, Upper: 20.41 |
| Estimates of CVg | 26.2 |
| Calculated Confidence Intervals of CVg | Lower: 21.78, Upper: 32.30 |
| Analytical CV | 3.6 |
| Calculated Confidence Intervals of Analytical CV | Lower: 2.82, Upper: 4.97 |
| Measurand Mean | 0.34 |
| Measurand Min | |
| Measurand Max | |
| Measurand SD |