EFLM Biological Varation Database : BIVAC Minimum Data Set for Aspartate transaminase (AST) EFLM Biological Variation

Aspartate transaminase (AST)

Reference

Williams GZ, Widdowson GM and Penton J, 1978, Clin Chem, 24, 313-20 , Individual Character of Variation in Time-Series Studies of Healthy People II. Differences in Values for Clinical Chemical Analytes in Serum among Demographic Groups by Age and Sex

Originally from this reference: Clin Chem, Williams GZ, Widdowson GM and Penton J, 1978

ID: 0165

Scoring

Total Score

C_4,5,8,10,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	B
4. Measurand	C
5. Pre-Analytical	C
6. Replicate Analysis	B
7. Steady State	B
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	C
11. ANOVA	B
12. CI	A
13. No of Results	C
14. Concentrations	A
15. Total Score	C_4,5,8,10,13
Comment	* obsolete method at 30°C)

Item Details

Parameter	Score
Matrix	Serum
Measurand	Aspartate transaminase (AST)
Unit	U / L
Overall Analytical Principle Method	Enzymatic analysis - Not specified
Number of Subjects	1105
Number of Subjects included in BV estimation	1105
Ethinicity	Caucasian
Age Mean / Median
Age Min	18.0
Age Max
Age SD
Number of Males	628
Number of Females	477
State of Well Being	Healthy (excl pregnant)
Study Duration Length	3
Study Duration Units	Month
Sampling Intervals, e.g. X sample(s) per Interval Unit	1
Interval Units	Week
Sampling Times	Start Time: 07:30 End Time: 10:00
Number of Samples	5
Average Number of Samples Used for BV Estimation	5.0
Average Number of Replicates	1.0
Estimates of CVi	21.4
Calculated Confidence Intervals of CVi	Lower: 0.00, Upper: 37.57
Estimates of CVg	30.7
Calculated Confidence Intervals of CVg	Lower: 19.26, Upper: 39.70
Analytical CV	7.36
Calculated Confidence Intervals of Analytical CV	Lower: 6.95, Upper: 7.82
Measurand Mean	14.0
Measurand Min
Measurand Max
Measurand SD

Coding

Parameter	Score
Healthy Population	true
Adult Population	true
Weekly Samplings	true
Reviewed	true
Published	true
Gender for Meta-Analysis	Mixed
Snomed CT
NPU
LOINC
Comment	method at 30°C

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