Aspartate transaminase (AST)


Williams GZ, Widdowson GM and Penton J, 1978, Clin Chem, 24, 313-20 , Individual Character of Variation in Time-Series Studies of Healthy People II. Differences in Values for Clinical Chemical Analytes in Serum among Demographic Groups by Age and Sex


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples B
4. Measurand D
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score D4
Comment * obsolete method at 30°C)

Item Details

Parameter Score
Matrix Serum
Measurand Aspartate transaminase (AST)
Unit U / L
Overall Analytical Principle Method Enzymatic analysis - Not specified
Number of Subjects 1105
Number of Subjects included in BV estimation 1105
Ethinicity Caucasian
Age Mean / Median
Age Min 18.0
Age Max
Age SD
Number of Males 628
Number of Females 477
State of Well Being
Healthy (excl pregnant)
Study Duration Length 3
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 07:30
End Time: 10:00
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 1.0
Estimates of CVi 21.4
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 37.57
Estimates of CVg 30.7
Calculated Confidence Intervals of CVg Lower: 19.26, Upper: 39.70
Analytical CV 7.36
Calculated Confidence Intervals of Analytical CV Lower: 6.95, Upper: 7.82
Measurand Mean 14.0
Measurand Min
Measurand Max
Measurand SD