EFLM Biological Varation Database : BIVAC Minimum Data Set for Aspartate transaminase (AST) EFLM Biological Variation

Aspartate transaminase (AST)

Reference

Horder M and Bowers GN, 1977, Clin Chem, 23, 551-4 , Biological variability in aspartate aminotransferase activity in serum of healthy persons, and effect of in vitro supplementation with pyridoxal 5-phosphate

Scoring

Total Score

C_4,8,10

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	C
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	B
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	B
12. CI	A
13. No of Results	A
14. Concentrations	A
15. Total Score	C_4,8,10
Comment	* obsolete method (IFCC at 30°C)

Item Details

Parameter	Score
Matrix	Serum
Measurand	Aspartate transaminase (AST)
Unit	U / L
Overall Analytical Principle Method	Enzymatic analysis - Not specified
Number of Subjects	6
Number of Subjects included in BV estimation	6
Ethinicity	Caucasian
Age Mean / Median
Age Min	24.0
Age Max	46.0
Age SD
Number of Males
Number of Females	6
State of Well Being	Healthy (excl pregnant)
Study Duration Length	15
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	4
Interval Units	Week
Sampling Times	Start Time: 09:00 End Time: 09:00
Number of Samples	8
Average Number of Samples Used for BV Estimation	8.0
Average Number of Replicates	2.0
Estimates of CVi	5.28
Calculated Confidence Intervals of CVi	Lower: 4.04, Upper: 7.01
Estimates of CVg	13.58
Calculated Confidence Intervals of CVg	Lower: 8.60, Upper: 30.18
Analytical CV	3.61
Calculated Confidence Intervals of Analytical CV	Lower: 3.01, Upper: 4.51
Measurand Mean	9.9
Measurand Min
Measurand Max
Measurand SD

Coding

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