Haemoglobin A1c (HbA1c)

Reference

Reference
Thyagarajan B, Howard AG, Durazo-Arvizu R, Eckfeldt JH, Gellman MD, Kim RS, Liu K, Mendez AJ, Penedo FJ, Talavera GA, Youngblood ME, Zhao L and Sotres-Alvarez D, 2016, Clin Chim Acta, 463, 129-137 , Analytical and biological variability in biomarker measurement in the Hispanic Community Health Study/Study of Latinos

Scoring

Total Score

C10,12

Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis B
9. Normality B
10. Variance Homogeneity C
11. ANOVA A
12. CI C
13. No of Results B
14. Concentrations A
15. Total Score C10,12
Comment 1) Data may not be used for estimation of RCV (9B). 2) Data is not necessarily representative for the total population (10C).

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Haemoglobin A1c (HbA1c)
Unit ug / ug
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 57
Number of Subjects included in BV estimation 57
Ethinicity Caucasian
Age Mean / Median 46.0
Age Min 18.0
Age Max 74.0
Age SD
Number of Males
Number of Females
State of Well Being
Healthy (excl pregnant)
Diseases
Study Duration Length 2.5
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 114
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 2.0
Estimates of CVi 2.2
Calculated Confidence Intervals of CVi Lower: 1.85, Upper: 2.71
Estimates of CVg 20.39
Calculated Confidence Intervals of CVg Lower: 17.22, Upper: 24.99
Analytical CV 0.6
Calculated Confidence Intervals of Analytical CV Lower: 0.53, Upper: 0.69
Measurand Mean 5.6
Measurand Min
Measurand Max
Measurand SD

Coding