Haemoglobin A1c (HbA1c)


Desmeules P, Cousineau J, Allard P, 2010, Ann Clin Biochem, 47, 35-8 , Biological variation of glycated haemoglobin in a paediatric population and its application to calculation of significant change between results


Total Score


Parameter Score
1. Scale B
2. Study Population A
3. Samples B
4. Measurand B
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations B
15. Total Score C5,7,8,10,13
Comment scale:%, CVA with CQI, no matix,

Item Details

Parameter Score
Matrix Unknown
Measurand Haemoglobin A1c (HbA1c)
Unit ug / ug
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 38
Number of Subjects included in BV estimation 38
Ethinicity Unknown
Age Mean / Median 14.0
Age Min 5.0
Age Max 18.0
Age SD
Number of Males 24
Number of Females 14
State of Well Being Non-healthy (excl pregnant)
Study Duration Length 60
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Year
Sampling Times Start Time:
End Time:
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 0.0
Estimates of CVi 4.8
Calculated Confidence Intervals of CVi Lower: 4.24, Upper: 5.46
Estimates of CVg 12.8
Calculated Confidence Intervals of CVg Lower: 10.38, Upper: 16.59
Analytical CV 1.4
Calculated Confidence Intervals of Analytical CV Lower: 1.06, Upper: 2.04
Measurand Mean
Measurand Min
Measurand Max
Measurand SD


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