Uncarboxylated-unphosphorylated matrix-Gla protein (uCuP-MGP)

Included in meta analysis


Cavalier E, Lukas P, Bottani M, Aarsand A.K., Ceriotti F, Coşkun A, Diaz-Garzón J, Fernàndez-Calle P, Guerra E, 10 & M. Locatelli, Sandberg S, Carobene A, & on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation and IOF-IFCC Committee on Bone Metabolism, 2020, Osteoporos Int, 31(8), 1461-1470 , European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates of β-isomerized C-terminal telopeptide of type I collagen (β-CTX), N-terminal propeptide of type I collagen (PINP), osteocalcin, intact fibroblast growth factor 23 and uncarboxylated-unphosphorylated matrix-Gla protein—a cooperation between the EFLM Working Group on Biological Variation and the International Osteoporosis Foundation-International Federation of Clinical Chemistry Committee on Bone Metabolism


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Uncarboxylated-unphosphorylated matrix-Gla protein (uCuP-MGP)
Unit pmol / L
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 91
Number of Subjects included in BV estimation 85
Ethinicity Caucasian
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 38
Number of Females 53
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 8:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 6.9
Calculated Confidence Intervals of CVi Lower: 6.37, Upper: 7.46
Estimates of CVg 13.9
Calculated Confidence Intervals of CVg Lower: 12.02, Upper: 16.44
Analytical CV 6.9
Calculated Confidence Intervals of Analytical CV Lower: 6.59, Upper: 7.24
Measurand Mean 397.0
Measurand Min 393.0
Measurand Max 401.0
Measurand SD