Anna Carobene*, Elisabet Gonzalez Lao, Margarida Simon, Massimo Locatelli, Abdurrahman Coşkun, Jorge Díaz-Garzón, Pilar Fernandez-Calle, Sverre Sandberg and Aasne K. Aarsand, , 2020, Clin Chem Lab Med, 60, 518-522 , Biological variation of serum insulin: updated estimates from the European Biological Variation Study (EuBIVAS) and meta-analysis


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Insulin
Unit microU / mL
Overall Analytical Principle Method Immunoassay; Other
Number of Subjects 38
Number of Subjects included in BV estimation 38
Ethinicity Caucasian
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 38
Number of Females 0
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08.00
End Time: 10.00
Number of Samples 10
Average Number of Samples Used for BV Estimation 1.97
Average Number of Replicates 2.0
Estimates of CVi 25.0
Calculated Confidence Intervals of CVi Lower: 20.29, Upper: 32.52
Estimates of CVg 31.9
Calculated Confidence Intervals of CVg Lower: 22.94, Upper: 43.66
Analytical CV 3.1
Calculated Confidence Intervals of Analytical CV Lower: 2.53, Upper: 4.00
Measurand Mean 7.53
Measurand Min 7.24
Measurand Max 7.83
Measurand SD