Reference
Anna Carobene*, Elisabet Gonzalez Lao, Margarida Simon, Massimo Locatelli, Abdurrahman Coşkun, Jorge Díaz-Garzón, Pilar Fernandez-Calle, Sverre Sandberg and Aasne K. Aarsand, , 2020, Clin Chem Lab Med, 60, 518-522 , Biological variation of serum insulin: updated estimates from the European Biological Variation Study (EuBIVAS) and meta-analysis
| Parameter | Score |
|---|---|
| 1. Scale | A |
| 2. Study Population | A |
| 3. Samples | A |
| 4. Measurand | A |
| 5. Pre-Analytical | A |
| 6. Replicate Analysis | A |
| 7. Steady State | A |
| 8. Outlier Analysis | A |
| 9. Normality | A |
| 10. Variance Homogeneity | A |
| 11. ANOVA | A |
| 12. CI | A |
| 13. No of Results | A |
| 14. Concentrations | A |
| 15. Total Score | A1,2,3,4,5,6,7,8,9,10,11,12,13,14 |
| Comment |
| Parameter | Score |
|---|---|
| Matrix | Serum |
| Measurand | Insulin |
| Unit | microU / mL |
| Overall Analytical Principle Method | Immunoassay; Other |
| Number of Subjects | 91 |
| Number of Subjects included in BV estimation | 90 |
| Ethinicity | Caucasian |
| Age Mean / Median | |
| Age Min | 21.0 |
| Age Max | 69.0 |
| Age SD | |
| Number of Males | 38 |
| Number of Females | 53 |
| State of Well Being |
Healthy (excl pregnant)
|
| Diseases | |
| Study Duration Length | 10 |
| Study Duration Units | Week |
| Sampling Intervals, e.g. X sample(s) per Interval Unit | 1 |
| Interval Units | Week |
| Sampling Times | Start Time:
08.00
End Time: 10.00 |
| Number of Samples | 10 |
| Average Number of Samples Used for BV Estimation | 1.97 |
| Average Number of Replicates | 2.0 |
| Estimates of CVi | 25.3 |
| Calculated Confidence Intervals of CVi | Lower: 22.01, Upper: 29.74 |
| Estimates of CVg | 33.4 |
| Calculated Confidence Intervals of CVg | Lower: 27.41, Upper: 40.70 |
| Analytical CV | 3.1 |
| Calculated Confidence Intervals of Analytical CV | Lower: 2.71, Upper: 3.63 |
| Measurand Mean | 7.65 |
| Measurand Min | 7.47 |
| Measurand Max | 7.83 |
| Measurand SD |