Included in meta analysis


Anna Carobene*, Elisabet Gonzalez Lao, Margarida Simon, Massimo Locatelli, Abdurrahman Coşkun, Jorge Díaz-Garzón, Pilar Fernandez-Calle, Sverre Sandberg and Aasne K. Aarsand, , 2020, Clin Chem Lab Med, 60, 518-522 , Biological variation of serum insulin: updated estimates from the European Biological Variation Study (EuBIVAS) and meta-analysis


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Insulin
Unit microU / mL
Overall Analytical Principle Method Immunoassay; Other
Number of Subjects 91
Number of Subjects included in BV estimation 90
Ethinicity Caucasian
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 38
Number of Females 53
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08.00
End Time: 10.00
Number of Samples 10
Average Number of Samples Used for BV Estimation 1.97
Average Number of Replicates 2.0
Estimates of CVi 25.3
Calculated Confidence Intervals of CVi Lower: 22.01, Upper: 29.74
Estimates of CVg 33.4
Calculated Confidence Intervals of CVg Lower: 27.41, Upper: 40.70
Analytical CV 3.1
Calculated Confidence Intervals of Analytical CV Lower: 2.71, Upper: 3.63
Measurand Mean 7.65
Measurand Min 7.47
Measurand Max 7.83
Measurand SD