Midttun Ø, Townsend MK, Nyga ̊rd O, Tworoger SS, Brennan P,Johansson M, Ueland PM, 2014, J Nutr, 144(5), 784-90 , Most Blood Biomarkers Related to Vitamin Status, One-Carbon Metabolism, and the Kynurenine Pathway Show Adequate Preanalytical Stability and Within-Person Reproducibility to Allow Assessment of Exposure or Nutritional Status in Healthy Women and Cardiovascular Patients


Total Score


Parameter Score
1. Scale A
2. Study Population D
3. Samples NA
4. Measurand NA
5. Pre-Analytical NA
6. Replicate Analysis NA
7. Steady State NA
8. Outlier Analysis NA
9. Normality NA
10. Variance Homogeneity NA
12. CI NA
13. No of Results NA
14. Concentrations NA
15. Total Score D2
Comment no information about health status of subjects is provided

Item Details

Parameter Score
Matrix Plasma
Measurand Folate
Unit nmol / L
Overall Analytical Principle Method Turbidimetry
Number of Subjects 40
Number of Subjects included in BV estimation 40
Ethinicity Caucasian
Age Mean / Median 62.0
Age Min 51.0
Age Max 68.0
Age SD
Number of Males 0
Number of Females 40
State of Well Being
Healthy (excl pregnant)
Study Duration Length 2
Study Duration Units Year
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Year
Sampling Times Start Time:
End Time:
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 1.0
Estimates of CVi 47.0
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 59.0
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean
Measurand Min
Measurand Max
Measurand SD