Lacher DA, Hughes JP and Carroll MD, 2005, Clin Chem, 51, 450-2 , Estimate of biological variation of laboratory analytes based on the third National Health and Nutrition Examination Survey


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples B
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis B
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C5,7,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Creatinine
Unit umol / L
Overall Analytical Principle Method Unknown
Number of Subjects 2062
Number of Subjects included in BV estimation 2062
Ethinicity Caucasian
Age Mean / Median 40.0
Age Min
Age Max
Age SD
Number of Males
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 84
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 1.0
Estimates of CVi 6.8
Calculated Confidence Intervals of CVi Lower: 5.32, Upper: 8.01
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV 1.0
Calculated Confidence Intervals of Analytical CV Lower: 0.94, Upper: 1.07
Measurand Mean 93.11
Measurand Min
Measurand Max
Measurand SD