Included in meta analysis


Cokluk E, Akbay HI, Alp HH, 2021, Clin Lab, 67(9), , Biological Variation of Iron, Transferrin, Ferritin, Folate, Vitamin B12 and 25-OH Vitamin D in Healthy Individuals


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations B
15. Total Score C5,8

Item Details

Parameter Score
Matrix Plasma
Measurand Iron
Unit Unknown / Unknown
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 21
Number of Subjects included in BV estimation 21
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max 50.0
Age SD
Number of Males 10
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 8:30
End Time: 10:0
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 27.3
Calculated Confidence Intervals of CVi Lower: 23.72, Upper: 32.16
Estimates of CVg 32.3
Calculated Confidence Intervals of CVg Lower: 23.50, Upper: 47.80
Analytical CV 0.67
Calculated Confidence Intervals of Analytical CV Lower: 0.59, Upper: 0.77
Measurand Mean 79.7
Measurand Min
Measurand Max
Measurand SD