Included in meta analysis


Coşkun A, Carobene A, Aarsand AK, Aksungar FB , Serteser M, Sandberg S, Díaz-Garzón J, Fernandez-Calle P, Karpuzoğlu FH, Coskun C, Kızılkaya E, Fidan D, Jonker N, Uğur E, Unsal I, on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation and Task Group for the Biological Variation Database, 2021 , Clin Chem Lab Med , aop, , Within- and between-subject biological variation data for serum zinc, copper and selenium obtained from 68 apparently healthy Turkish subjects


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Copper
Unit micromol / L
Overall Analytical Principle Method MS; ICP-MS
Number of Subjects 32
Number of Subjects included in BV estimation 32
Ethinicity Caucasian
Age Mean / Median 29.5
Age Min 19.0
Age Max 50.0
Age SD
Number of Males 32
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08.00
End Time: 10.30
Number of Samples 9
Average Number of Samples Used for BV Estimation 8.8
Average Number of Replicates 1.94
Estimates of CVi 7.8
Calculated Confidence Intervals of CVi Lower: 7.14, Upper: 8.58
Estimates of CVg 11.9
Calculated Confidence Intervals of CVg Lower: 9.43, Upper: 15.91
Analytical CV 2.2
Calculated Confidence Intervals of Analytical CV Lower: 2.02, Upper: 2.42
Measurand Mean 15.2
Measurand Min 15.1
Measurand Max 15.4
Measurand SD