Aakre KM, Ottesend AH, Strandf H, Faareng AL, Alaourh B, Torsvik J, Sylte MS, Marber M, Christensen G, Helge Røsjø H, Omlande T, 2021, Clin Biochem, aop, aop , Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis


Total Score


Parameter Score
1. Scale B
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B1,6

Item Details

Parameter Score
Matrix Serum
Measurand Folate
Unit ug / ug
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 11
Number of Subjects included in BV estimation
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max 50.0
Age SD
Number of Males
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 8:30
End Time: 10:00
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 9.44
Calculated Confidence Intervals of CVi Lower: 7.61, Upper: 12.15
Estimates of CVg 22.27
Calculated Confidence Intervals of CVg Lower: 15.45, Upper: 38.29
Analytical CV 4.27
Calculated Confidence Intervals of Analytical CV Lower: 3.60, Upper: 5.25
Measurand Mean 7.55
Measurand Min 7.16
Measurand Max 7.94
Measurand SD