Cokluk E, Akbay HI, Alp HH, 2021, Clin Lab, 67(9), , Biological Variation of Iron, Transferrin, Ferritin, Folate, Vitamin B12 and 25-OH Vitamin D in Healthy Individuals


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B2,6

Item Details

Parameter Score
Matrix Serum
Measurand Folate
Unit ug / ug
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 21
Number of Subjects included in BV estimation 21
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max 50.0
Age SD
Number of Males 10
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 8:30
End Time: 10:00
Number of Samples 5
Average Number of Samples Used for BV Estimation 4.86
Average Number of Replicates 2.0
Estimates of CVi 10.3
Calculated Confidence Intervals of CVi Lower: 8.76, Upper: 12.35
Estimates of CVg 28.56
Calculated Confidence Intervals of CVg Lower: 21.74, Upper: 41.12
Analytical CV 4.71
Calculated Confidence Intervals of Analytical CV Lower: 4.09, Upper: 5.55
Measurand Mean 6.54
Measurand Min 6.23
Measurand Max 6.85
Measurand SD