Included in meta analysis


Aakre KM, Ottesend AH, Strandf H, Faareng AL, Alaourh B, Torsvik J, Sylte MS, Marber M, Christensen G, Helge Røsjø H, Omlande T, 2021, Clin Biochem, aop, aop , Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis C
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results B
14. Concentrations B
15. Total Score C6,8,10,11,12

Item Details

Parameter Score
Matrix Serum
Measurand Folate
Unit pmol / mL
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 8
Number of Subjects included in BV estimation
Ethinicity Asian
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males
Number of Females 8
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Day
Sampling Times Start Time: 8:30
End Time:
Number of Samples
Average Number of Samples Used for BV Estimation
Average Number of Replicates
Estimates of CVi 28.6
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 25.8
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean
Measurand Min
Measurand Max
Measurand SD