Tumor necrosis factor (TNF)


Fernández-Calle P, Díaz-Garzón J, Bartlett W, Sandberg S, Braga F, Beatriz B, Carobene A, Coskun A, Gonzalez-Lao E, Marques F, Perich C, Simon M, Aarsand AK, EFLM Working Group on Biological Variation and Task Group for the Biological Variation Database , 2021, Clin Chem Lab Med , , aop , Biological variation estimates of thyroid related measurands – meta-analysis of BIVAC compliant studies


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI C
13. No of Results B
14. Concentrations A
15. Total Score C12

Item Details

Parameter Score
Matrix Serum
Measurand Tumor necrosis factor (TNF)
Unit pg / mL
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 4
Number of Subjects included in BV estimation 4
Ethinicity Caucasian
Age Mean / Median 30.7
Age Min 25.0
Age Max 36.0
Age SD
Number of Males 4
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 8:00
End Time: 9:30
Number of Samples 6
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 1.0
Estimates of CVi 51.0
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 85.75
Estimates of CVg 34.0
Calculated Confidence Intervals of CVg Lower: 0.00, Upper: 120.36
Analytical CV 12.9
Calculated Confidence Intervals of Analytical CV Lower: 5.76, Upper: 411.64
Measurand Mean 3.69
Measurand Min
Measurand Max
Measurand SD