Tumor necrosis factor (TNF)


Cava F, Gonza ́lez C, Pascual MJ, Navajo JA, Gonza ́lez-Buitrago JM, 2000, CYTOKINE, 12(9), 1423–1425 , Biological variation of interleukin 6 (IL-6) and soluble interleukin 2 receptor (sIL2R) in serum of healthy individuals


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI C
13. No of Results B
14. Concentrations A
15. Total Score C12

Item Details

Parameter Score
Matrix Serum
Measurand Tumor necrosis factor (TNF)
Unit pg / mL
Overall Analytical Principle Method Chemiluminescence
Number of Subjects 11
Number of Subjects included in BV estimation
Ethinicity Caucasian
Age Mean / Median 39.6
Age Min 28.5
Age Max 51.0
Age SD
Number of Males
Number of Females 11
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 8:00
End Time: 9:30
Number of Samples 6
Average Number of Samples Used for BV Estimation 6.0
Average Number of Replicates 1.0
Estimates of CVi 42.0
Calculated Confidence Intervals of CVi Lower: 31.66, Upper: 52.44
Estimates of CVg 19.0
Calculated Confidence Intervals of CVg Lower: 0.00, Upper: 40.47
Analytical CV 12.9
Calculated Confidence Intervals of Analytical CV Lower: 8.31, Upper: 28.41
Measurand Mean 2.93
Measurand Min
Measurand Max
Measurand SD