Interleukin-6 (IL6)


Engelberger RP, Limacher A, Kucher N, Baumann F, Silbernagel G, Benghozi R et al, 2015, Clin Chim Acta, 447, 16-22 , Biological variation of established and novel biomarkers for atherosclerosis: Results from a prospective, parallel-group cohort study


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples B
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis C
7. Steady State B
8. Outlier Analysis B
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C6,10,11,13

Item Details

Parameter Score
Matrix Serum
Measurand Interleukin-6 (IL6)
Unit pg / mL
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 62
Number of Subjects included in BV estimation
Ethinicity Caucasian
Age Mean / Median 64.7
Age Min 59.0
Age Max 71.0
Age SD
Number of Males 49
Number of Females 13
State of Well Being
Non-healthy (excl pregnant)
  • Heart disease
Study Duration Length 1
Study Duration Units Year
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 1.0
Estimates of CVi 46.8
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 43.6
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean 3.33
Measurand Min 2.95
Measurand Max 3.75
Measurand SD