Tumor necrosis factor (TNF)

Included in meta analysis


Todd J, Simpson P, Estis J, Torres V, Wub A HB, 2013, Cytokine, 64, 660–665 , Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis A
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C5,10

Item Details

Parameter Score
Matrix Plasma
Measurand Tumor necrosis factor (TNF)
Unit pg / mL
Overall Analytical Principle Method Immunoassay; Other
Number of Subjects 17
Number of Subjects included in BV estimation
Ethinicity Unknown
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 9
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 8:00
End Time: 10:00
Number of Samples 9
Average Number of Samples Used for BV Estimation 9.0
Average Number of Replicates 2.0
Estimates of CVi 21.0
Calculated Confidence Intervals of CVi Lower: 18.43, Upper: 24.19
Estimates of CVg 28.0
Calculated Confidence Intervals of CVg Lower: 20.41, Upper: 42.79
Analytical CV 10.8
Calculated Confidence Intervals of Analytical CV Lower: 9.71, Upper: 12.16
Measurand Mean
Measurand Min
Measurand Max
Measurand SD