Tumor necrosis factor (TNF)

Included in meta analysis


Aziz N, Detels R, Quint JJ, Gjertson D, Ryner T, Butch AW, 2019, BMC Immunol, 20(33), , Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis B
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B8

Item Details

Parameter Score
Matrix Serum
Measurand Tumor necrosis factor (TNF)
Unit pg / mL
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 12
Number of Subjects included in BV estimation 12
Ethinicity Unknown
Age Mean / Median
Age Min 21.0
Age Max 51.0
Age SD
Number of Males 6
Number of Females 6
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 9:00
End Time: 11:00
Number of Samples 12
Average Number of Samples Used for BV Estimation
Average Number of Replicates 2.0
Estimates of CVi 12.7
Calculated Confidence Intervals of CVi Lower: 10.98, Upper: 14.79
Estimates of CVg 27.2
Calculated Confidence Intervals of CVg Lower: 19.30, Upper: 45.21
Analytical CV 8.2
Calculated Confidence Intervals of Analytical CV Lower: 7.35, Upper: 9.27
Measurand Mean 12.63
Measurand Min
Measurand Max
Measurand SD