Aarsand AK, Diaz-Garzón J, Fernández-Calle P, et al, 2018, Clin Chem, 64(9), 1380-93 , The EuBIVAS: within- and between-subject biological variation data for electrolytes, lipids, urea, uric acid, total protein, total bilirubin, direct bilirubin and glucose


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Bilirubin
Unit mg / dL
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 37
Number of Subjects included in BV estimation 37
Ethinicity Caucasian
Age Mean / Median 45.0
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 37
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 9.38
Average Number of Replicates 2.0
Estimates of CVi 21.7
Calculated Confidence Intervals of CVi Lower: 20.10, Upper: 23.57
Estimates of CVg 25.3
Calculated Confidence Intervals of CVg Lower: 20.20, Upper: 33.25
Analytical CV 2.98
Calculated Confidence Intervals of Analytical CV Lower: 2.77, Upper: 3.22
Measurand Mean 0.81
Measurand Min 0.77
Measurand Max 0.84
Measurand SD