Aziz N, Detels R, Quint JJ, Gjertson D, Ryner T, Butch AW, 2019, BMC Immunol, 20(33), , Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests


Total Score


Parameter Score
1. Scale A
2. Study Population B
3. Samples B
4. Measurand C
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C4,5,8,10,11,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Adiponectin
Unit ug / mL
Overall Analytical Principle Method Unknown
Number of Subjects 12
Number of Subjects included in BV estimation 12
Ethinicity Unknown
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males 6
Number of Females 6
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Other
Sampling Times Start Time:
End Time:
Number of Samples 6
Average Number of Samples Used for BV Estimation
Average Number of Replicates 1.0
Estimates of CVi 15.9
Calculated Confidence Intervals of CVi Lower: 13.12, Upper: 19.52
Estimates of CVg 48.1
Calculated Confidence Intervals of CVg Lower: 34.17, Upper: 79.87
Analytical CV 3.7
Calculated Confidence Intervals of Analytical CV Lower: 2.45, Upper: 7.53
Measurand Mean 6.29
Measurand Min
Measurand Max
Measurand SD