Included in meta analysis


Harris EK, Kanofsky P, Shakarji G and Cotlove E, 1970, Clin Chem, 16, 1022-7 , Biological and analytic components of variation in long-term studies of serum constituents in normal subjects


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Urate
Unit mg / dL
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 21
Number of Subjects included in BV estimation 21
Ethinicity Caucasian
Age Mean / Median 30.0
Age Min 20.0
Age Max 59.0
Age SD
Number of Males
Number of Females 21
State of Well Being
Healthy (excl pregnant)
Study Duration Length 11
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08.30
End Time: 9.00
Number of Samples 12
Average Number of Samples Used for BV Estimation 12.0
Average Number of Replicates 2.0
Estimates of CVi 10.1
Calculated Confidence Intervals of CVi Lower: 9.20, Upper: 11.17
Estimates of CVg 13.5
Calculated Confidence Intervals of CVg Lower: 10.20, Upper: 19.53
Analytical CV 3.5
Calculated Confidence Intervals of Analytical CV Lower: 3.22, Upper: 3.83
Measurand Mean
Measurand Min
Measurand Max
Measurand SD