Included in meta analysis


Braga F, Szőke D, Valente C, Panteghini M, 2013, Clinica Chimica Acta, 415, 295-6 , Biologic variation of copper, ceruloplasmin and copper/ceruloplasmin ratio (Cu:Cp) in serum


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State C
8. Outlier Analysis B
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C7,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Copper
Unit micromol / L
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 19
Number of Subjects included in BV estimation 19
Ethinicity Unknown
Age Mean / Median
Age Min 23.0
Age Max 48.0
Age SD
Number of Males 10
Number of Females 9
State of Well Being
Healthy (excl pregnant)
Study Duration Length 2
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Week
Sampling Times Start Time: 09:00
End Time:
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 5.8
Calculated Confidence Intervals of CVi Lower: 4.80, Upper: 7.10
Estimates of CVg 14.5
Calculated Confidence Intervals of CVg Lower: 10.87, Upper: 21.39
Analytical CV 3.7
Calculated Confidence Intervals of Analytical CV Lower: 3.24, Upper: 4.31
Measurand Mean 11.5
Measurand Min
Measurand Max
Measurand SD