Carobene A, Guerra E, Marques-Garcia F, Boned B, Locatelli M, Coşkun A, Díaz-Garzón J, Fernandez-Calle P, Sandberg S, Aarsand AK, 2020 Oct, Clin Chim Acta, 509, 268-272 , Biological variation of morning serum cortisol: Updated estimates from the European biological variation study (EuBIVAS) and meta-analysis


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand Cortisol
Unit nmol / L
Overall Analytical Principle Method Immunoassay; Non-competitive
Number of Subjects 38
Number of Subjects included in BV estimation 10
Ethinicity Unknown
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 38
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 8.0
Average Number of Replicates 2.0
Estimates of CVi 15.9
Calculated Confidence Intervals of CVi Lower: 13.58, Upper: 19.13
Estimates of CVg 20.6
Calculated Confidence Intervals of CVg Lower: 13.77, Upper: 37.06
Analytical CV 3.6
Calculated Confidence Intervals of Analytical CV Lower: 3.12, Upper: 4.26
Measurand Mean 302.0
Measurand Min 295.0
Measurand Max 308.0
Measurand SD