Included in meta analysis


González-Revaldería J., García-Bermejo S., Mench én-Herreros A., and Fernández-Rodriguez E, 1990, Clin Chem, 36, 2140-41 , Biological variation of Zn, Cu, and Mg in serum of healthy subjects


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Copper
Unit micromol / L
Overall Analytical Principle Method Spectrophotometry; Atomic absorption
Number of Subjects 15
Number of Subjects included in BV estimation 15
Ethinicity Unknown
Age Mean / Median
Age Min 25.0
Age Max 40.0
Age SD
Number of Males 5
Number of Females 10
State of Well Being
Healthy (excl pregnant)
Study Duration Length 4
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 8.00
End Time: 9.30
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 2.0
Estimates of CVi 5.6
Calculated Confidence Intervals of CVi Lower: 4.63, Upper: 7.07
Estimates of CVg 13.6
Calculated Confidence Intervals of CVg Lower: 9.86, Upper: 21.31
Analytical CV 0.9
Calculated Confidence Intervals of Analytical CV Lower: 0.76, Upper: 1.10
Measurand Mean 14.4
Measurand Min
Measurand Max
Measurand SD 0.1