Costongs GMPJ, Janson PCW and Bas BM, 1985, J Clin Chem Clin Biochem, 23, 7-16 , Short-term and long-term intra-individual variations and critical differences of clinical chemical laboratory parameters


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand C
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C4,8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Transferrin
Unit g / L
Overall Analytical Principle Method Unknown
Number of Subjects 62
Number of Subjects included in BV estimation 62
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max 53.0
Age SD
Number of Males 23
Number of Females 39
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit 4
Interval Units Day
Sampling Times Start Time: 8.30
End Time: 16.30
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates
Estimates of CVi 3.0
Calculated Confidence Intervals of CVi Lower: 2.31, Upper: 3.50
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV 1.9
Calculated Confidence Intervals of Analytical CV Lower: 1.48, Upper: 2.64
Measurand Mean 3.2
Measurand Min
Measurand Max
Measurand SD