Loh TP and Metz MP, 2015, Am J Clin Pathol, 143, 683-93 , Indirect estimation of pediatric between-individual biological variation data from 22 common serum biochemistries


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples B
4. Measurand C
5. Pre-Analytical C
6. Replicate Analysis C
7. Steady State C
8. Outlier Analysis B
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations B
15. Total Score C4,5,6,7,10,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Albumin
Unit g / L
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 3030
Number of Subjects included in BV estimation 3030
Ethinicity Caucasian
Age Mean / Median
Age Min 0.0
Age Max 19.0
Age SD
Number of Males
Number of Females 3030
State of Well Being
Healthy (excl pregnant)
Study Duration Length 12
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 6
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 2
Average Number of Samples Used for BV Estimation 2.0
Average Number of Replicates 1.0
Estimates of CVi 3.0
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 7.2
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean
Measurand Min
Measurand Max
Measurand SD