Reference
Carobene A, Guerra E, Marques-Garcia F, Boned B, Locatelli M, Coşkun A, Díaz-Garzón J, Fernandez-Calle P, Sandberg S, Aarsand AK, 2020 Oct, Clin Chim Acta, 509, 268-272 , Biological variation of morning serum cortisol: Updated estimates from the European biological variation study (EuBIVAS) and meta-analysis
| Parameter | Score |
|---|---|
| 1. Scale | A |
| 2. Study Population | A |
| 3. Samples | A |
| 4. Measurand | A |
| 5. Pre-Analytical | A |
| 6. Replicate Analysis | A |
| 7. Steady State | A |
| 8. Outlier Analysis | A |
| 9. Normality | A |
| 10. Variance Homogeneity | A |
| 11. ANOVA | A |
| 12. CI | A |
| 13. No of Results | A |
| 14. Concentrations | A |
| 15. Total Score | A1,2,3,4,5,6,7,8,9,10,11,12,13,14 |
| Comment | Women post-menopausal (>50 years) |
| Parameter | Score |
|---|---|
| Matrix | Serum |
| Measurand | Cortisol |
| Unit | nmol / L |
| Overall Analytical Principle Method | Immunoassay; Non-competitive |
| Number of Subjects | 10 |
| Number of Subjects included in BV estimation | 10 |
| Ethinicity | Unknown |
| Age Mean / Median | |
| Age Min | 21.0 |
| Age Max | 69.0 |
| Age SD | |
| Number of Males | |
| Number of Females | 10 |
| State of Well Being |
Healthy (excl pregnant)
|
| Diseases | |
| Study Duration Length | 10 |
| Study Duration Units | Week |
| Sampling Intervals, e.g. X sample(s) per Interval Unit | 1 |
| Interval Units | Week |
| Sampling Times | Start Time:
08:00
End Time: 10:00 |
| Number of Samples | 10 |
| Average Number of Samples Used for BV Estimation | 9.0 |
| Average Number of Replicates | 2.0 |
| Estimates of CVi | 14.1 |
| Calculated Confidence Intervals of CVi | Lower: 12.14, Upper: 16.76 |
| Estimates of CVg | 26.6 |
| Calculated Confidence Intervals of CVg | Lower: 18.26, Upper: 47.18 |
| Analytical CV | 3.6 |
| Calculated Confidence Intervals of Analytical CV | Lower: 3.14, Upper: 4.22 |
| Measurand Mean | 349.0 |
| Measurand Min | 333.0 |
| Measurand Max | 366.0 |
| Measurand SD |