Carobene A, Guerra E, Marques-Garcia F, Boned B, Locatelli M, Coşkun A, Díaz-Garzón J, Fernandez-Calle P, Sandberg S, Aarsand AK, 2020 Oct, Clin Chim Acta, 509, 268-272 , Biological variation of morning serum cortisol: Updated estimates from the European biological variation study (EuBIVAS) and meta-analysis


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14
Comment Women pre-menopausal (<50 years)

Item Details

Parameter Score
Matrix Serum
Measurand Cortisol
Unit nmol / L
Overall Analytical Principle Method Immunoassay; Non-competitive
Number of Subjects 43
Number of Subjects included in BV estimation 43
Ethinicity Unknown
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males
Number of Females 43
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 9.0
Average Number of Replicates 2.0
Estimates of CVi 14.9
Calculated Confidence Intervals of CVi Lower: 13.83, Upper: 16.14
Estimates of CVg 36.3
Calculated Confidence Intervals of CVg Lower: 29.86, Upper: 46.16
Analytical CV 3.6
Calculated Confidence Intervals of Analytical CV Lower: 3.36, Upper: 3.87
Measurand Mean 414.0
Measurand Min 401.0
Measurand Max 428.0
Measurand SD