Included in meta analysis


Van der Veen A, van Faassen M, De Jong WHA et al, 2019, Clin Biochem, , , Development and validation of a LC-MS/MS method for the establishment of reference intervals and biological variation for five plasma steroid hormones


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations B
15. Total Score B14

Item Details

Parameter Score
Matrix Plasma
Measurand Androstenedione
Unit nmol / L
Overall Analytical Principle Method MS; HPLC-MS
Number of Subjects 15
Number of Subjects included in BV estimation 15
Ethinicity Unknown
Age Mean / Median
Age Min 21.0
Age Max 63.0
Age SD
Number of Males 15
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 5
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 12:00
End Time: 12:00
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 18.1
Calculated Confidence Intervals of CVi Lower: 15.35, Upper: 22.05
Estimates of CVg 32.1
Calculated Confidence Intervals of CVg Lower: 23.04, Upper: 50.59
Analytical CV 1.8
Calculated Confidence Intervals of Analytical CV Lower: 1.55, Upper: 2.14
Measurand Mean
Measurand Min
Measurand Max
Measurand SD