Cembrowski G, Tran DV and Higgins TN, 2010, Clin Chem Lab Med, 48, 1447-54 , The use of serial patient blood gas, electrolyte and glucose results to derive biological variation: a new tool to assess the acceptability of intensive care unit testing


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis C
7. Steady State C
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results A
14. Concentrations A
15. Total Score C6,7,8,10,11,12

Item Details

Parameter Score
Matrix Whole blood
Measurand Glucose
Unit mmol / L
Overall Analytical Principle Method Ion-selective electrode
Number of Subjects 1676
Number of Subjects included in BV estimation 1676
Ethinicity Unknown
Age Mean / Median
Age Min
Age Max
Age SD
Number of Males
Number of Females
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 12
Study Duration Units Hour
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Hour
Sampling Times Start Time:
End Time:
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 9.9
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg 5.8
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean
Measurand Min
Measurand Max
Measurand SD