C-reactive protein (CRP)

Included in meta analysis


Sakkinen PA, Macy EM, Callas PW, Cornell ES, Hayes TE, Kuller LH and Tracy RP, 1999, Am J Epidem, 149, 261-7 , Analytical and biologic variability in measures of hemostasis, fibrinolysis and inflammation: assesment and implications for epidemiology


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis B
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C10,13

Item Details

Parameter Score
Matrix Serum
Measurand C-reactive protein (CRP)
Unit ug / mL
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 26
Number of Subjects included in BV estimation 26
Ethinicity Caucasian
Age Mean / Median
Age Min 23.0
Age Max 72.0
Age SD
Number of Males 10
Number of Females 16
State of Well Being
Healthy (excl pregnant)
Study Duration Length 24
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time:
End Time:
Number of Samples 8
Average Number of Samples Used for BV Estimation 8.0
Average Number of Replicates 2.0
Estimates of CVi 49.8
Calculated Confidence Intervals of CVi Lower: 45.14, Upper: 55.53
Estimates of CVg 94.0
Calculated Confidence Intervals of CVg Lower: 73.20, Upper: 129.87
Analytical CV 5.2
Calculated Confidence Intervals of Analytical CV Lower: 4.74, Upper: 5.75
Measurand Mean 1.5
Measurand Min
Measurand Max
Measurand SD