C-reactive protein (CRP)


Rudez G, Meiher P, Spronk HMH, Leebeek FWG, Cate HT, Kluft C and de Maat MPM, 2009, J Thromb Hemost, 7, 1247-55 , Biological variation in inflammatory and hemostatic markers


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State C
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results B
14. Concentrations A
15. Total Score C7,8,10

Item Details

Parameter Score
Matrix Plasma
Measurand C-reactive protein (CRP)
Unit mg / L
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 40
Number of Subjects included in BV estimation 40
Ethinicity Unknown
Age Mean / Median 41.0
Age Min 21.0
Age Max 70.0
Age SD
Number of Males 14
Number of Females 26
State of Well Being
Healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Year
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: 09:00
End Time: 10:00
Number of Samples 13
Average Number of Samples Used for BV Estimation 13.0
Average Number of Replicates 1.0
Estimates of CVi 77.7
Calculated Confidence Intervals of CVi Lower: 73.07, Upper: 82.95
Estimates of CVg 107.6
Calculated Confidence Intervals of CVg Lower: 87.47, Upper: 138.74
Analytical CV 3.0
Calculated Confidence Intervals of Analytical CV Lower: 2.52, Upper: 3.71
Measurand Mean 0.37
Measurand Min
Measurand Max
Measurand SD