C-reactive protein (CRP)


Macy EM, Hayes TE, Tracy RP, 1997, Clin Chem, 43, 52-8 , Variability in the measuraments of C-reactive protein in healthy subjets: implications for reference intervals and epidemiological applications


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical C
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C5,10

Item Details

Parameter Score
Matrix Serum
Measurand C-reactive protein (CRP)
Unit mg / L
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 26
Number of Subjects included in BV estimation 26
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max 67.0
Age SD
Number of Males 10
Number of Females 16
State of Well Being
Healthy (excl pregnant)
Study Duration Length 6
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Month
Sampling Times Start Time: -
End Time: -
Number of Samples 8
Average Number of Samples Used for BV Estimation 8.0
Average Number of Replicates 1.0
Estimates of CVi 42.2
Calculated Confidence Intervals of CVi Lower: 38.22, Upper: 47.10
Estimates of CVg 92.5
Calculated Confidence Intervals of CVg Lower: 72.24, Upper: 127.54
Analytical CV 5.2
Calculated Confidence Intervals of Analytical CV Lower: 3.98, Upper: 7.51
Measurand Mean 1.7
Measurand Min
Measurand Max
Measurand SD