Included in meta analysis


Clark GH, Fraser CG. , 1993, Ann Clin Biochem, 30, 373-76 , Biological variation of acute phase proteins


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations A
15. Total Score C8,10,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Transthyretin
Unit mg / L
Overall Analytical Principle Method Immunoturbidimetry
Number of Subjects 19
Number of Subjects included in BV estimation 19
Ethinicity Unknown
Age Mean / Median
Age Min 20.0
Age Max 46.0
Age SD
Number of Males 9
Number of Females 10
State of Well Being
Healthy (excl pregnant)
Study Duration Length 5
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Month
Sampling Times Start Time: 09:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 10.9
Calculated Confidence Intervals of CVi Lower: 9.81, Upper: 12.24
Estimates of CVg 19.1
Calculated Confidence Intervals of CVg Lower: 14.34, Upper: 28.15
Analytical CV 3.2
Calculated Confidence Intervals of Analytical CV Lower: 2.91, Upper: 3.56
Measurand Mean 265.0
Measurand Min
Measurand Max
Measurand SD