a-1 antitrypsin

Included in meta analysis


Carobene A, Aarsand AK, Guerra E et al, 2019, Clin Chem, 65 (8), 1031-41 , Within- and Between-Subject Biological VariationData for 15 Frequently Measured Proteins


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Item Details

Parameter Score
Matrix Serum
Measurand a-1 antitrypsin
Unit mg / dL
Overall Analytical Principle Method Immunoturbidimetry
Number of Subjects 91
Number of Subjects included in BV estimation 86
Ethinicity Caucasian
Age Mean / Median
Age Min 21.0
Age Max 69.0
Age SD
Number of Males 38
Number of Females 53
State of Well Being Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 10:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 9.29
Average Number of Replicates 1.95
Estimates of CVi 3.8
Calculated Confidence Intervals of CVi Lower: 3.60, Upper: 4.02
Estimates of CVg 10.1
Calculated Confidence Intervals of CVg Lower: 8.77, Upper: 11.90
Analytical CV 1.38
Calculated Confidence Intervals of Analytical CV Lower: 1.31, Upper: 1.45
Measurand Mean 112.9
Measurand Min
Measurand Max
Measurand SD


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