Neuron specific enolase

Included in meta analysis


Matyar S, Goruroglu Ozturk O et al, 2016, J Clin Lab Anal, 30(6), 1081-5 , Biological variation and reference change value data for serum neuron-specific enolase in a turkish population


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality B
10. Variance Homogeneity C
12. CI C
13. No of Results C
14. Concentrations B
15. Total Score C10,12,13
Comment C10,12,13

Item Details

Parameter Score
Matrix Serum
Measurand Neuron specific enolase
Unit Unknown / Unknown
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 13
Number of Subjects included in BV estimation 13
Ethinicity Unknown
Age Mean / Median
Age Min 23.0
Age Max 36.0
Age SD
Number of Males 6
Number of Females 7
State of Well Being
Healthy (excl pregnant)
Study Duration Length 2
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Week
Sampling Times Start Time: 08:00
End Time: 09:00
Number of Samples 8
Average Number of Samples Used for BV Estimation
Average Number of Replicates 6.0
Estimates of CVi 21.5
Calculated Confidence Intervals of CVi Lower: 18.67, Upper: 25.28
Estimates of CVg 28.8
Calculated Confidence Intervals of CVg Lower: 20.16, Upper: 47.41
Analytical CV 10.2
Calculated Confidence Intervals of Analytical CV Lower: 9.62, Upper: 10.86
Measurand Mean
Measurand Min
Measurand Max
Measurand SD