Reference
Tuxen MK, Sölétormos G, Petersen PH and Dombernowsky P, 2001, Clin Chem Lab Med, 39, 531-8 , Interpretation of sequential measurements of cancer Antigen 125 (CA 125), Carcinoembryonic Antigen (CEA) and Tissue Polypeptide Antigen (TPA) based on analytical imprecision and biological variation in the monitoring of ovarian cancer
| Parameter | Score |
|---|---|
| 1. Scale | A |
| 2. Study Population | A |
| 3. Samples | A |
| 4. Measurand | A |
| 5. Pre-Analytical | A |
| 6. Replicate Analysis | B |
| 7. Steady State | A |
| 8. Outlier Analysis | C |
| 9. Normality | A |
| 10. Variance Homogeneity | A |
| 11. ANOVA | A |
| 12. CI | A |
| 13. No of Results | C |
| 14. Concentrations | A |
| 15. Total Score | C8,13 |
| Comment |
| Parameter | Score |
|---|---|
| Matrix | Serum |
| Measurand | Cancer antigen 125 (CA-125) |
| Unit | U / L |
| Overall Analytical Principle Method | Immunoassay; RIA |
| Number of Subjects | 31 |
| Number of Subjects included in BV estimation | 31 |
| Ethinicity | Caucasian |
| Age Mean / Median | 55.0 |
| Age Min | 32.0 |
| Age Max | 71.0 |
| Age SD | |
| Number of Males | |
| Number of Females | 31 |
| State of Well Being |
Healthy (excl pregnant)
|
| Diseases | |
| Study Duration Length | 1 |
| Study Duration Units | Year |
| Sampling Intervals, e.g. X sample(s) per Interval Unit | |
| Interval Units | Week |
| Sampling Times | Start Time:
End Time: |
| Number of Samples | 16 |
| Average Number of Samples Used for BV Estimation | 16.0 |
| Average Number of Replicates | 2.0 |
| Estimates of CVi | 20.0 |
| Calculated Confidence Intervals of CVi | Lower: 18.69, Upper: 21.48 |
| Estimates of CVg | |
| Calculated Confidence Intervals of CVg | Lower: , Upper: |
| Analytical CV | 7.8 |
| Calculated Confidence Intervals of Analytical CV | Lower: 7.34, Upper: 8.32 |
| Measurand Mean | 0.8 |
| Measurand Min | |
| Measurand Max | |
| Measurand SD |