EFLM Biological Varation Database : BIVAC Minimum Data Set for Cancer antigen 125 (CA-125) EFLM Biological Variation

Cancer antigen 125 (CA-125)

Reference

Tuxen MK, Sölétormos G, Petersen PH and Dombernowsky P, 2001, Clin Chem Lab Med, 39, 531-8 , Interpretation of sequential measurements of cancer Antigen 125 (CA 125), Carcinoembryonic Antigen (CEA) and Tissue Polypeptide Antigen (TPA) based on analytical imprecision and biological variation in the monitoring of ovarian cancer

Scoring

Total Score

C_8,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	B
7. Steady State	A
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	A
11. ANOVA	A
12. CI	A
13. No of Results	C
14. Concentrations	A
15. Total Score	C_8,13
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	Cancer antigen 125 (CA-125)
Unit	U / L
Overall Analytical Principle Method	Immunoassay; RIA
Number of Subjects	31
Number of Subjects included in BV estimation	31
Ethinicity	Caucasian
Age Mean / Median	55.0
Age Min	32.0
Age Max	71.0
Age SD
Number of Males
Number of Females	31
State of Well Being	Healthy (excl pregnant)
Study Duration Length	1
Study Duration Units	Year
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units	Week
Sampling Times	Start Time: End Time:
Number of Samples	16
Average Number of Samples Used for BV Estimation	16.0
Average Number of Replicates	2.0
Estimates of CVi	20.0
Calculated Confidence Intervals of CVi	Lower: 18.69, Upper: 21.48
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: , Upper:
Analytical CV	7.8
Calculated Confidence Intervals of Analytical CV	Lower: 7.34, Upper: 8.32
Measurand Mean	0.8
Measurand Min
Measurand Max
Measurand SD

Coding

© 2018 - 2019 This website and its content is copyright of EFLM. All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited other than the following: you may print or download to a local hard disk extracts for your personal and non-commercial use only you may copy the content to individual third parties for their personal use, but only if you acknowledge the website as the source of the material You may not, except with our express written permission, distribute or commercially exploit the content. Nor may you transmit it or store it in any other website or other form of electronic retrieval system.