Meijers WC, Van del Velde AR, Kobold ACM, et al, 2017, Eur J Hearth Failure , 19, 357-65 , Variability of biomarkers in patients with chronic heart failure and healthy controls


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples B
4. Measurand A
5. Pre-Analytical B
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C8,10

Item Details

Parameter Score
Matrix Plasma
Measurand Renin
Unit ng / L
Overall Analytical Principle Method Immunoassay; RIA
Number of Subjects 83
Number of Subjects included in BV estimation 83
Ethinicity Unknown
Age Mean / Median 64.0
Age Min
Age Max
Age SD 10.0
Number of Males 79
Number of Females 4
State of Well Being
Non-healthy (excl pregnant)
Study Duration Length 3
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 3
Average Number of Samples Used for BV Estimation 3.0
Average Number of Replicates
Estimates of CVi 32.6
Calculated Confidence Intervals of CVi Lower: 29.43, Upper: 36.55
Estimates of CVg 222.2
Calculated Confidence Intervals of CVg Lower: 192.70, Upper: 262.28
Analytical CV 2.3
Calculated Confidence Intervals of Analytical CV Lower: 1.80, Upper: 3.20
Measurand Mean 74.0
Measurand Min 18.0
Measurand Max 200.0
Measurand SD