N-telopeptide crosslinks (NTx)


Alvarez L, Ricós C, Peris P, Guañabens N, Monegal A,Pons F and Ballesta AM, 2000, Bone, 26, 571-6 , Components of biological variation of biochemical markers of bone tumor in Paget’s bone disease

Originally from this reference: Bone, Alvarez L, Ricós C, Peris P, Guañabens N, Monegal A,Pons F and Ballesta AM, 2000

ID: 0171


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI C
13. No of Results A
14. Concentrations A
15. Total Score C8,10,12

Item Details

Parameter Score
Matrix Urine
Measurand N-telopeptide crosslinks (NTx)
Unit nM / mmol creatinine
Overall Analytical Principle Method Immunoassay; ELISA
Number of Subjects 15
Number of Subjects included in BV estimation 15
Ethinicity Unknown
Age Mean / Median 40.0
Age Min 28.0
Age Max 49.0
Age SD 6.2
Number of Males
Number of Females 15
State of Well Being Non-healthy (excl pregnant)
Study Duration Length 1
Study Duration Units Year
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Month
Sampling Times Start Time: 8:00
End Time: 10:00
Number of Samples 4
Average Number of Samples Used for BV Estimation 4.0
Average Number of Replicates 2.0
Estimates of CVi 15.8
Calculated Confidence Intervals of CVi Lower: 12.85, Upper: 20.19
Estimates of CVg 51.2
Calculated Confidence Intervals of CVg Lower: 37.40, Upper: 79.83
Analytical CV 6.3
Calculated Confidence Intervals of Analytical CV Lower: 5.35, Upper: 7.67
Measurand Mean 248.0
Measurand Min
Measurand Max
Measurand SD


Parameter Score
Healthy Population false
Adult Population true
Weekly Samplings false
Reviewed false
Published false
Gender for Meta-Analysis Females
Snomed CT