EFLM Biological Varation Database : BIVAC Minimum Data Set for C-terminal cross-linked telopeptide of type I collagen (CTX) EFLM Biological Variation

C-terminal cross-linked telopeptide of type I collagen (CTX)

Reference

Alvarez L, Ricós C, Peris P, Guañabens N, Monegal A,Pons F and Ballesta AM, 2000, Bone, 26, 571-6 , Components of biological variation of biochemical markers of bone tumor in Paget’s bone disease

Scoring

Total Score

C_8,10,12

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	A
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	C
11. ANOVA	A
12. CI	C
13. No of Results	A
14. Concentrations	A
15. Total Score	C_8,10,12
Comment

Item Details

Parameter	Score
Matrix	Urine
Measurand	C-terminal cross-linked telopeptide of type I collagen (CTX)
Unit	ug / mmol creatinine
Overall Analytical Principle Method	Immunoassay; ELISA
Number of Subjects	15
Number of Subjects included in BV estimation	15
Ethinicity	Unknown
Age Mean / Median	40.0
Age Min	28.0
Age Max	49.0
Age SD	6.2
Number of Males
Number of Females	15
State of Well Being	Healthy (excl pregnant)
Study Duration Length	1
Study Duration Units	Year
Sampling Intervals, e.g. X sample(s) per Interval Unit	3
Interval Units	Month
Sampling Times	Start Time: 8:00 End Time: 10:00
Number of Samples	4
Average Number of Samples Used for BV Estimation	4.0
Average Number of Replicates	2.0
Estimates of CVi	25.6
Calculated Confidence Intervals of CVi	Lower: 21.09, Upper: 32.42
Estimates of CVg	36.3
Calculated Confidence Intervals of CVg	Lower: 25.18, Upper: 58.22
Analytical CV	6.2
Calculated Confidence Intervals of Analytical CV	Lower: 5.26, Upper: 7.55
Measurand Mean	128.1
Measurand Min
Measurand Max
Measurand SD

Coding

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