EFLM Biological Varation Database : BIVAC Minimum Data Set for Prostate specific antigen (PSA)

Prostate specific antigen (PSA) - Conjugated

Reference

Nixon RG, Wener MH, Smith KM, Parson RE, Blase AB and Brawer MK, 1997, Prost Cancer and Prost diseas, 1, 90-6 , Day to day changes in free and total PSA: significance of biological variation

Scoring

Total Score

C_7,8,10,11,13

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	B
7. Steady State	C
8. Outlier Analysis	C
9. Normality	A
10. Variance Homogeneity	C
11. ANOVA	C
12. CI	A
13. No of Results	C
14. Concentrations	A
15. Total Score	C_7,8,10,11,13
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	Prostate specific antigen (PSA) - Conjugated
Unit	% / %
Overall Analytical Principle Method	Immunoassay; Other
Number of Subjects	24
Number of Subjects included in BV estimation	24
Ethinicity	Unknown
Age Mean / Median	72.6
Age Min	67.0
Age Max	83.0
Age SD
Number of Males	24
Number of Females	0
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	2
Study Duration Units	Week
Sampling Intervals, e.g. X sample(s) per Interval Unit	1
Interval Units	Day
Sampling Times	Start Time: End Time:
Number of Samples	10
Average Number of Samples Used for BV Estimation	10.0
Average Number of Replicates	2.0
Estimates of CVi	8.8
Calculated Confidence Intervals of CVi	Lower: 7.74, Upper: 10.00
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: , Upper:
Analytical CV	7.0
Calculated Confidence Intervals of Analytical CV	Lower: 6.43, Upper: 7.69
Measurand Mean	15.3
Measurand Min	3.8
Measurand Max	37.5
Measurand SD

Coding

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