EFLM Biological Varation Database : BIVAC Minimum Data Set for Carcinoembryonic antigen (CEA) EFLM Biological Variation

Carcinoembryonic antigen (CEA)

Reference

Plebani M, Giacomini A, Beghi L, De Paoli M, Roveroni G, Galleotti F, Corsini A, Fraser CG, 1996, Anticancer Res, 16, 2249-52 , Serum tumor markers in monitoring patients: interpretation of results using analytical and biological variation

Scoring

Total Score

C_8,10,12,13

Parameter	Score
1. Scale	A
2. Study Population	B
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	A
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	B
12. CI	C
13. No of Results	C
14. Concentrations	A
15. Total Score	C_8,10,12,13
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	Carcinoembryonic antigen (CEA)
Unit	ug / L
Overall Analytical Principle Method	Immunoassay; Other
Number of Subjects	9
Number of Subjects included in BV estimation	9
Ethinicity	Unknown
Age Mean / Median	61.0
Age Min
Age Max
Age SD
Number of Males	5
Number of Females	4
State of Well Being	Non-healthy (excl pregnant)
Study Duration Length	2
Study Duration Units	Day
Sampling Intervals, e.g. X sample(s) per Interval Unit	6
Interval Units	Hour
Sampling Times	Start Time: 08:00 End Time: 18:00
Number of Samples	6
Average Number of Samples Used for BV Estimation	6.0
Average Number of Replicates	1.0
Estimates of CVi	10.9
Calculated Confidence Intervals of CVi	Lower: 5.38, Upper: 14.12
Estimates of CVg	178.0
Calculated Confidence Intervals of CVg	Lower: 122.38, Upper: 325.04
Analytical CV	4.3
Calculated Confidence Intervals of Analytical CV	Lower: 2.68, Upper: 10.55
Measurand Mean	7.4
Measurand Min
Measurand Max
Measurand SD

Coding

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