Keevil BG, Kilpatrick ES, Nichols SP and Maylor PW, 1998, Clin Chem, 44, 1535-9 , Biological variation of cystatin C: implications for the assesment of glomerular filtration rate


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Creatinine
Unit micromol / L
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 12
Number of Subjects included in BV estimation
Ethinicity Caucasian
Age Mean / Median 40.0
Age Min 21.0
Age Max 55.0
Age SD
Number of Males 7
Number of Females 5
State of Well Being
Healthy (excl pregnant)
Study Duration Length 18
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 3
Interval Units Month
Sampling Times Start Time: 14:00
End Time: 15:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 4.9
Calculated Confidence Intervals of CVi Lower: 4.18, Upper: 5.80
Estimates of CVg 18.2
Calculated Confidence Intervals of CVg Lower: 13.00, Upper: 30.13
Analytical CV 3.1
Calculated Confidence Intervals of Analytical CV Lower: 2.75, Upper: 3.55
Measurand Mean 86.0
Measurand Min
Measurand Max
Measurand SD