Included in meta analysis


Young DS, Harris EK and Cotlove E, 1971, Clin Chem, 17, 403-10 , Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. IV. Results of a study designed to eliminate long-term analytic deviations.


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis C
9. Normality B
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Creatinine
Unit mg / dL
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 9
Number of Subjects included in BV estimation 9
Ethinicity Caucasian
Age Mean / Median
Age Min 27.0
Age Max 34.0
Age SD
Number of Males 9
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 10
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:30
End Time: 09:00
Number of Samples 10
Average Number of Samples Used for BV Estimation 10.0
Average Number of Replicates 2.0
Estimates of CVi 4.38
Calculated Confidence Intervals of CVi Lower: 3.59, Upper: 5.37
Estimates of CVg 7.04
Calculated Confidence Intervals of CVg Lower: 4.70, Upper: 13.07
Analytical CV 3.2
Calculated Confidence Intervals of Analytical CV Lower: 2.79, Upper: 3.75
Measurand Mean 1.05
Measurand Min
Measurand Max
Measurand SD