EFLM Biological Varation Database : BIVAC Minimum Data Set for Creatinine EFLM Biological Variation

Creatinine

Reference

Rosano TG and Brown HH, 1982, Clin Chem, 28, 2330-1 , Analytical and biological variability of serum creatinine and creatinine clearance: implications for clinical interpretation

Scoring

Total Score

C_8,10,11

Parameter	Score
1. Scale	A
2. Study Population	A
3. Samples	A
4. Measurand	A
5. Pre-Analytical	A
6. Replicate Analysis	A
7. Steady State	B
8. Outlier Analysis	C
9. Normality	B
10. Variance Homogeneity	C
11. ANOVA	C
12. CI	A
13. No of Results	A
14. Concentrations	A
15. Total Score	C_8,10,11
Comment

Item Details

Parameter	Score
Matrix	Serum
Measurand	Creatinine
Unit	mg / L
Overall Analytical Principle Method	Spectrophotometry; UV/VISIBLE
Number of Subjects	2
Number of Subjects included in BV estimation	2
Ethinicity	Caucasian
Age Mean / Median
Age Min	33.0
Age Max	55.0
Age SD
Number of Males	2
Number of Females
State of Well Being	Healthy (excl pregnant)
Study Duration Length	2
Study Duration Units	Month
Sampling Intervals, e.g. X sample(s) per Interval Unit	3
Interval Units	Week
Sampling Times	Start Time: End Time:
Number of Samples	24
Average Number of Samples Used for BV Estimation	24.0
Average Number of Replicates	2.0
Estimates of CVi	7.9
Calculated Confidence Intervals of CVi	Lower: 5.78, Upper: 10.57
Estimates of CVg
Calculated Confidence Intervals of CVg	Lower: , Upper:
Analytical CV	6.7
Calculated Confidence Intervals of Analytical CV	Lower: 5.59, Upper: 8.37
Measurand Mean	11.9
Measurand Min
Measurand Max
Measurand SD

Coding

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