Pickup JF, Harris EK, Kearns M and Brown SS, 1977, Clin Chem, 23, 842-50 , Intra-individual variation of some serum constituents and its relevance to population-based reference ranges


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis B
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score C10

Item Details

Parameter Score
Matrix Serum
Measurand Albumin
Unit g / L
Overall Analytical Principle Method Spectrophotometry; Other
Number of Subjects 37
Number of Subjects included in BV estimation 37
Ethinicity Caucasian
Age Mean / Median
Age Min 23.0
Age Max 57.0
Age SD
Number of Males 37
Number of Females
State of Well Being
Healthy (excl pregnant)
Study Duration Length 22
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 08:45
End Time: 09:30
Number of Samples 22
Average Number of Samples Used for BV Estimation 22.0
Average Number of Replicates 1.0
Estimates of CVi 3.2
Calculated Confidence Intervals of CVi Lower: , Upper:
Estimates of CVg
Calculated Confidence Intervals of CVg Lower: , Upper:
Analytical CV
Calculated Confidence Intervals of Analytical CV Lower: , Upper:
Measurand Mean 48.43
Measurand Min
Measurand Max
Measurand SD